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Save the following code to agno_assist.py:
agno_assist.py
from agno.agent import Agent
from agno.db.sqlite import SqliteDb
from agno.models.anthropic import Claude
from agno.os import AgentOS
from agno.tools.mcp import MCPTools

agno_assist = Agent(
    name="Agno Assist",
    model=Claude(id="claude-sonnet-4-5"),
    db=SqliteDb(db_file="agno.db"),
    tools=[MCPTools(url="https://docs.agno.com/mcp")],
    add_datetime_to_context=True,
    add_history_to_context=True,
    num_history_runs=3,
    markdown=True,
)

agent_os = AgentOS(agents=[agno_assist])
app = agent_os.get_app()
In ~20 lines: an Agent with memory, state and MCP, served as a FastAPI application.

Run Your AgentOS

1

Set up your virtual environment

uv venv --python 3.12
source .venv/bin/activate
2

Install dependencies

uv pip install -U 'agno[os]' anthropic mcp
3

Export your Anthropic API key

export ANTHROPIC_API_KEY=sk-***
4

Run your AgentOS

fastapi dev agno_agent.py
Your AgentOS is now running at http://localhost:8000.
EndpointDescription
http://localhost:8000Connect to the control plane
http://localhost:8000/docsInteractive API documentation
http://localhost:8000/configView AgentOS configuration